Table 4.
Z-statistics for MRI white matter hyper-intensities volume and cortical thickness measures from regression models for the EF outcomes, controlling for age, education, gender, any APOE-ε4 alleles, and intracranial volume. Bolded coefficients indicate p-values <0.05
EF score | White Matter Hyper-intensities |
Caudal Middle Frontal |
Rostral Middle Frontal |
Superior Middle Frontal |
Lateral Orbito-frontal |
Medial Orbito-Frontal |
Pars- triangularis |
---|---|---|---|---|---|---|---|
ADNI-EF | −2.09 | 2.29 | 3.52 | 2.88 | 3.80 | 2.34 | 2.61 |
Category Fluency | −0.58 | 1.14 | 2.01 | 1.91 | 3.24 | 2.58 | 2.19 |
Clock Drawing | 1.00 | 3.14 | 3.12 | 2.97 | 2.49 | 1.66 | 1.73 |
WAIS-R Digit Symbol | −2.31 | 1.23 | 2.52 | 2.23 | 2.94 | 1.88 | 1.30 |
Digit Span Backwards | −1.61 | 0.05 | 1.47 | −0.11 | 1.44 | 1.29 | 0.61 |
Trails Aa | −0.56 | 1.20 | 1.05 | 0.24 | 1.20 | 0.36 | 0.82 |
Trails Ba | −1.71 | 2.83 | 3.56 | 2.85 | 3.14 | 1.47 | 3.01 |
Trails B–Trails Aa | −1.77 | 2.88 | 3.73 | 3.14 | 3.21 | 1.56 | 3.03 |
Trails scores were reversed so higher scores are better for all outcomes