Correlation of functional brain activation with contralesional anterior motor cortex (left). Shown are significant seed correlations (p<0.05, clusters of >100 contiguous voxels) with the contralesional anterior motor cortex. Enhanced recruitment of cerebellar-thalamo-cortical circuit and cerebellar-basal ganglia-cortical circuit in response to right, unilateral cortical impact injury (Lesion) and of lesioned animals in response to physostigmine administration (Lesion/Phy). Abbreviations: Au, auditory cortex; CA1, CA2, hippocampus CA1, CA2; CPu, striatum; M1, primary motor cortex; M2, secondary motor cortex; dl-CPu, dorsolateral striatum; Pir, piriform cortex; Pt, parietal cortex; S1HL/S1FL/S1Tr, primary somatosensory cortex of the hindlimb/forelimb/trunk; S2, secondary somatosensory cortex; STN/ZI, subthalamic n./zona incerta; VL, ventrolateral thalamus; V1, primary visual cortex; V2, secondary visual cortex. Color image is available online at www.liebertpub.com/neu