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Effects of acetyl salicylic acid, NS 398, naproxen, and indomethacin on H,K-ATPase activity. Gastric microsomes suspended in ATPase assay buffer at pH 7.4 were incubated for 30 min with varying concentrations of acetyl salicylic acid, NS 398, naproxen, or indomethacin and ATPase activity was then measured at pH 7.4. The data-points show mean SCH28080-sensitive ATPase activity measured in triplicate in one of three independent assays; typical data are shown in each case.
