Table 1.
Covariate | Overall (N=11) | Group E-C (N=5) | Group C-E (N=6) |
---|---|---|---|
Age (years) | 12.7 (2.1) | 13.0 (1.87) | 12.5 (2.43) |
Male | 2 (18.2%) | 0 (0.0%) | 2 (33.3%) |
BMI (kg/m2) | 36.7 (4.8) | 37.4 (4.18) | 36.2 (5.59) |
Weight (kg) | 93.8 (20.6) | 94.4 (17.2) | 93.3 (24.7) |
Body Fat (%) | 47.9 (5.27) | 48.7 (4.39) | 47.3 (6.25) |
Heart Rate (bpm) | 78.9 (15.6) | 79.8 (22.8) | 78.2 (8.5) |
SBP (mmHg) | 119 (6.9) | 119 (9.04) | 118 (5.47) |
DBP (mmHg) | 58.9 (10.2) | 64.0 (11.4) | 54.7 (7.47) |
Cholesterol (mg/dL) | 145 (20.8) | 143 (26.8) | 146 (17.1) |
LDL (mg/dL) | 85.6 (23.6) | 88.4 (25.1) | 83.3 (24.4) |
HDL (mg/dL) | 36.5 (5.89) | 35.4 (4.72) | 37.3 (7.03) |
Triglycerides (mg/dL) | 90.7 (31.7) | 97.2 (30.1) | 84.2 (35.3) |
ALT (U/L) | 21.82 (9.23) | 17.60 (10.36) | 25.33 (7.20) |
AST (U/L) | 31.18 (11.93) | 26.40 (6.47) | 35.17 (14.47) |
Glucose (mg/dL) | 75.4 (4.11) | 73.8 (3.03) | 76.7 (4.68) |
Glucose AUC (per 100) | 51.1 (24.4) | 45.4 (21.1) | 55.9 (27.8) |
Insulin (mU/L) | 14.6 (6.15) | 17.0 (5.29) | 13.0 (6.6) |
Insulin AUC (per 100) | 132 (68.6) | 100 (32.3) | 153 (80.6) |
WBISI/Matuda | 2.88 (1.31) | 2.88 (0.52) | 2.88 (1.79) |
β-Cell Function | 8.56 (3.94) | 7.47 (2.05) | 9.43 (5.07) |
CRP (mg/L) | 1.79 (1.55) | 1.26 (1.09) | 2.32 (1.86) |
IL-6 (pg/mL) | 3.21 (1.76) | 3.85 (2.05) | 2.67 (1.44) |
TNF-a (pg/mL) | 1.36 (0.76) | 1.47 (0.92) | 1.26 (0.67) |
Adiponectin (μg/mL) | 16.1 (5.0) | 15.9 (2.08) | 16.2 (6.81) |
Leptin (ng/mL) | 135 (54.0) | 143 (47.4) | 128 (62.6) |
OxLDL (U/L) | 42.9 (7.81) | 42.2 (8.68) | 43.5 (7.8) |
VCAM-1 (ng/mL) | 580 (139.8) | 564 (156.7) | 594 (137.7) |
vWF (U/mL) | 23.0 (9.3) | 24.8 (5.99) | 21.5 (11.8) |
RHI | 1.83 (0.48) | 1.84 (0.44) | 1.82 (0.55) |
Values presented are mean (SD) or N (%) where indicated. E = exenatide; C = control. Two participants in group C-E only completed the control phase (the first 3-months).