Table 2.
Estimated treatment effects within and between study arms.
| Outcome | Δ Control | Δ Exenatide | Treatment Effect (95% CI) | P-value |
|---|---|---|---|---|
| BMI (kg/m2) | 0.84 (1.28) | −0.90 (1.22) | −1.71 (−3.01, −0.42) | 0.010 |
| Percent BMI | 1.72 (4.19) | −2.57 (3.46) | −4.92 (−8.61, −1.23) | 0.009 |
| Weight (kg) | 2.97 (2.88) | −0.99 (2.90) | −3.90 (−7.11, −0.69) | 0.017 |
| Percent Weight | 2.68 (3.71) | −1.20 (3.19) | −4.58 (−8.12, −1.04) | 0.011 |
| Body Fat (%) | 0.92 (2.75) | −0.36 (3.07) | −1.28 (−4.66, 2.09) | 0.457 |
| Heart Rate (bpm) | −4.80 (7.45) | 2.22 (11.26) | 7.60 (−3.01, 18.21) | 0.160 |
| SBP (mmHg) | 3.10 (8.72) | −3.11 (8.51) | −5.31 (−14.89, 4.27) | 0.277 |
| DBP (mmHg) | −0.30 (13.91) | −1.78 (11.96) | −3.00 (−18.33, 12.33) | 0.701 |
| Cholesterol (mg/dL) | −8.60 (18.31) | 4.33 (19.54) | 10.70 (−11.92, 33.32) | 0.354 |
| LDL (mg/dL) | −4.50 (16.75) | 2.89 (16.70) | 6.93 (−11.77, 25.62) | 0.468 |
| HDL (mg/dL) | −0.20 (6.84) | 3.44 (3.40) | 3.25 (−2.47, 8.97) | 0.266 |
| Triglycerides (mg/dL) | −4.22 (37.45) | −9.89 (41.24) | −12.57 (−59.41, 34.28) | 0.599 |
| ALT (U/L) | 0.89 (10.49) | 0.71 (7.63) | 1.48 (−10.65, 13.60) | 0.811 |
| AST (U/L) | −3.67 (3.61) | 3.29 (3.64) | 6.04 (2.54, 9.54) | <0.001 |
| Glucose (mg/dL) | 1.60 (6.40) | 3.22 (5.85) | 1.68 (−3.65, 7.01) | 0.537 |
| Glucose AUC (per 100) | 11.69 (29.50) | −17.67 (22.98) | −27.96 (−56.51, 0.59) | 0.055 |
| Insulin (mU/L) | 6.00 (5.58) | −1.62 (8.42) | −7.54 (−13.71, −1.37) | 0.017 |
| Insulin AUC (per 100) | 30.29 (98.76) | −38.95 (73.74) | −76.01 (−166.30, 14.28) | 0.099 |
| WBISI/Matuda | −2.00 (3.52) | 4.12 (7.10) | 6.13 (1.01, 11.25) | 0.019 |
| β-Cell Function | −1.16 (6.33) | 14.50 (26.09) | 17.97 (1.40, 34.54) | 0.034 |
| CRP (mg/L) | −0.50 (0.76) | −0.36 (1.66) | 0.12 (−1.11, 1.34) | 0.853 |
| IL-6 (pg/mL) | −0.54 (0.78) | −0.83 (1.62) | −0.35 (−1.21, 0.50) | 0.419 |
| TNF-a (pg/mL) | −0.16 (0.49) | −0.33 (0.67) | −0.17 (−0.82, 0.48) | 0.610 |
| Adiponectin (μg/mL) | −1.35 (5.47) | −0.20 (3.93) | 0.98 (−4.22, 6.17) | 0.712 |
| Leptin (ng/mL) | −7.95 (41.31) | −12.71 (22.02) | −4.44 (−40.29, 31.41) | 0.808 |
| OxLDL (U/L) | −0.73 (7.49) | −0.40 (5.02) | 0.34 (−5.44, 6.13) | 0.907 |
| VCAM-1 (ng/mL) | 73.31 (154.41) | −7.37 (142.68) | −79.33 (−252.28, 93.63) | 0.369 |
| vWF (U/mL) | −3.81 (11.24) | −2.17 (10.87) | 2.08 (−10.97, 15.12) | 0.755 |
| RHI | 0.23 (0.65) | −0.03 (0.69) | −0.26 (−0.88, 0.36) | 0.413 |
Values presented are mean (SD).