Table 3.
Multiple myeloma risk for select anthropometric, behavioral, and reproductive characteristics from pooled analyses of the Los Angeles Multiple Myeloma case–control (LAMMCC) study and the California Teachers Study (CTS) cohort with matched controls (10:1).
| AllΔ | WomenΔ | ||||||
|---|---|---|---|---|---|---|---|
| cases/ contro ls |
OR | 95% CI | cases/ contro ls |
OR | 95% CI | P- heterogen eity |
|
| Anthropometric characteristics | |||||||
| Height at interview/Q1 (inches) | |||||||
| Tertile 1 | 115/48 2 |
1.00 | - | 74/441 | 1.00 | - | |
| Tertile 2 | 174/73 4 |
1.20 | (0.89- 1.62) |
115/68 5 |
1.21 | (0.85- 1.72) |
|
| Tertile 3 | 137/56 9 |
1.18 | (0.86- 1.61) |
86/507 | 1.39 | (0.95- 2.02) |
|
| p-trend=0.33 |
p-
trend=0.1 0 |
0.52 | |||||
| Weight at interview/baseline (pounds) | |||||||
| Tertile 1 | 133/56 0 |
1.00 | - | 89/510 | 1.00 | ||
| Tertile 2 | 134/56 3 |
0.95 | (0.71- 1.28) |
83/515 | 0.87 | (0.61- 1.23) |
|
| Tertile 3 | 152/57 3 |
0.95 | (0.71- 1.27) |
97/519 | 0.88 | (0.62- 1.24) |
|
| p-trend=0.65 | p-trend=0.34 | 0.93 | |||||
| BMI at interview/baseline* (kg/m2) | |||||||
| <25 | 205/90 6 |
1.00 | - | 147/85 1 |
1.00 | - | |
| 25-29.9 | 137/52 6 |
0.79 | (0.60- 1.04) |
72/452 | 0.79 | (0.57- 1.11) |
|
| 30-34.9 | 55/195 | 0.85 | (0.58- 1.24) |
36/176 | 0.83 | (0.53- 1.30) |
|
| 35+ | 22/69 | 1.05 | (0.59- 1.88) |
14/65 | 0.91 | (0.46- 1.80) |
|
| p-trend=0.49 | p-trend=0.38 | 0.63 | |||||
| Weight at 18 years (pounds) | |||||||
| Tertile 1 | 140/55 2 |
1.00 | - | 96/503 | 1.00 | ||
| Tertile 2 | 138/55 5 |
1.15 | (0.85- 1.56) |
84/503 | 1.14 | (0.80- 1.63) |
|
| Tertile 3 | 138/57 8 |
1.17 | (0.86- 1.59) |
88/529 | 1.18 | (0.83- 1.70) |
|
|
p-
trend=0.3 0 |
p-
trend=0.3 3 |
0.28 | |||||
| BMI at 18* (kg/m2) | |||||||
| <20 | 134/55 3 |
1.00 | - | 103/52 0 |
1.00 | ||
| 20-21.9 | 125/58 0 |
0.87 | (0.64- 1.19) |
80/540 | 0.78 | (0.54- 1.11) |
|
| 22+ | 155/53 9 |
1.02 | (0.75- 1.39) |
83/462 | 1.07 | (0.75- 1.53) |
0.29 |
| Smoking*∞ | |||||||
| Never | 205/10 73 |
1.00 | - | 153/10 25 |
1.00 | ||
| Ever | 223/71 9 |
1.07 | (0.84- 1.37) |
123/61 5 |
1.09 | (0.83- 1.44) |
0.15 |
| Current | 51/117 | 0.97 | (0.64- 1.47) |
26/85 | 1.11 | (0.67- 1.87) |
|
| Former | 172/60 2 |
1.10 | (0.84- 1.42) |
97/530 | 1.09 | (0.81- 1.46) |
|
| Alcohol* | |||||||
| Never | 186/62 8 |
1.00 | - | 132/58 2 |
1.00 | - | |
| Ever | 230/11 42 |
0.79 | (0.61- 1.02) |
132/10 37 |
0.78 | (0.58- 1.06) |
0.74 |
| Female reproductive characteristics | |||||||
| Number of pregnancies◇ | |||||||
| 0 | 32/268 | 1.04 | (0.66- 1.66) |
||||
| 1-2 | 84/602 | 1.00 | - | ||||
| 3+ | 156/73 6 |
1.38 |
(1.01
- 1.90) |
0.35 | |||
| Number of live births◇ | |||||||
| 0 | 46/334 | 1.14 | (0.77- 1.70) |
||||
| 1-2 | N/A | 102/73 9 |
1.00 | - | |||
| 3+ | 124/53 4 |
1.50 |
(1.09-
2.06) |
0.61 | |||
| Menopausal status | |||||||
| Natural menopause | 119/80 8 |
1.00 | 0.01 | ||||
| Surgical menopause (hysterectomy or oopherectomy) |
109/43 8 |
1.33 | (0.97- 1.83) |
||||
| Premenopausal | 26/210 | 0.60 | (0.30- 1.21) |
||||
| Other/unknown | 24/190 | 1.25 | (0.75- 2.07) |
||||
Δ
Matched on sex, date of birth +/− 5 years, and race Additional adjustments for individual models include:
*
education level
◇
age at menarche
∞
Malcohol