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. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: Dev Cell. 2012 Nov 13;23(5):921–923. doi: 10.1016/j.devcel.2012.10.025

Figure 1. IRE1α-mediated signaling of life and death.

Figure 1

Dimerization of IRE1α induces its activation and initiates downstream signaling through the recruitment of TRAF2 and RNase activation to promote Xbp1 mRNA splicing, degradation of mRNAs, and degradation of miRNAs.