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. 2013 May 15;33(20):8640–8649. doi: 10.1523/JNEUROSCI.5532-12.2013

Figure 1.

Figure 1.

Conditional viral restoration of D1R expression in either the NAcCore or the NAcShell. A, Schematic representation of Drd1aCre allele and AAV-FLEX-D1RGFP construct. B, Left, D1R protein expression is highly enriched in the striatum. Right, mouse brain atlas, bregma +1.34 (Franklin and Paxinos, 2007). C, Higher magnification of NAcCore region from B. D1R is completely absent in D1R mutants, but selectively expressed in the NAcCore with AAV-FLEX-D1RGFP. D, Higher magnification of NAcShell region from B. D1R is completely absent in D1R mutants, but selectively expressed in the NAcShell with AAV-FLEX-D1RGFP. E, F, Tracing of bilateral D1RGFP expression in D1R-NAcCore (n = 7) and D1R-NAcShell (n = 9) mice. Scale bars: B, 500 μm; C, D, 100 μm. ac, Anterior commissure. Data are shown as means ± SEM.