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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Clin Cancer Res. 2012 Dec 12;19(3):571–585. doi: 10.1158/1078-0432.CCR-12-2123

Figure 5. HGF-dependent regulation of GLUT1 expression in breast cancer.

Figure 5

HGF protein expression is elevated in coculture (cc) models compared to monocultures of RMF, MCF7 and SUM149 cells(A). Cytokine arrays identify HGF as a key factor significantly induced in coculture for both luminal and basal-like breast cancer cells (B), when blocked using an HGF neutralizing antibody (α-HGF), the GLUT1 receptor is inhibited at the RNA level (C). Levels of glucose uptake decrease by 66% (p=0.055) in SUM149 cells when HGF is inhibited using antibody (D).