Table 1. Characteristics of breast cancer samples by two clusters according to metabolite expression.
| Total | Cluster 1 – good prognosis (N=18) | Cluster 2 – poor prognosis (N=15) | ||||
|---|---|---|---|---|---|---|
| N | N | % | N | % | p value | |
| ER status | ||||||
| Positive | 20 | 13 | 61.1 | 7 | 38.9 | |
| Negative | 10 | 3 | 41.7 | 7 | 58.3 | 0.122 |
| Missing | 3 | 2 | 66.7 | 1 | 33.3 | |
| Size | ||||||
| <= 2 cm | 7 | 7 | 100 | 0 | 0 | |
| < 2 cm to <= 5cm | 12 | 5 | 41.7 | 7 | 58.3 | |
| < 5cm | 5 | 2 | 40 | 3 | 60 | 0.047 |
| Direct extension to chest wall or skin | 7 | 3 | 42.9 | 4 | 57.1 | |
| Missing | 2 | 1 | 50 | 1 | 50 | |
| Tumor subtype§ | ||||||
| Basal | 10 | 4 | 40 | 6 | 60 | |
| HER2 | 3 | 1 | 66.7 | 2 | 33.3 | |
| Luminal A | 10 | 9 | 90 | 1 | 10 | 0.064 |
| Luminal B | 6 | 2 | 33.3 | 4 | 66.7 | |
| Claudin-low | 3 | 1 | 33.3 | 2 | 66.7 | |
| Normal-like | 1 | 1 | 100 | 0 | 0 | |
| Tumor Grade | ||||||
| Well differentiated/1 | 2 | 2 | 100 | 0 | 0 | |
| Intermediate/2 | 7 | 5 | 71.4 | 2 | 28.6 | 0.135 |
| Poorly differentiated/3 | 20 | 8 | 40 | 12 | 60 | |
| Missing | 4 | 3 | 75 | 1 | 25 | |
| Node# | ||||||
| Negative | 21 | 12 | 57.1 | 9 | 42.9 | |
| Positive | 10 | 5 | 50 | 5 | 50 | 0.991 |
| Unknown | 2 | 1 | 50 | 1 | 50 | |
| Age | ||||||
| 30-39 | 5 | 2 | 40 | 3 | 60 | |
| 40-49 | 5 | 3 | 60 | 2 | 40 | |
| 50-59 | 5 | 3 | 60 | 2 | 40 | 0.952 |
| <= 60 | 16 | 9 | 56.3 | 7 | 43.7 | |
| Unknown | 2 | 1 | 50 | 1 | 50 | |
§
Classified using PAM50 algorithm applied to microarray data.
#
Negative means no positive lymph nodes. Positive is at least one positive lymph node.