Table 1.
List of downregulated genes
| Symbol | Gene name | Ptf1a | FC | Ascl1 | FC |
|---|---|---|---|---|---|
| Tfap2b | Transcription factor AP-2β | ++ | 12 | n.s. | |
| Gad1 | Glutamic acid decarboxylase 1 | ++ | 3.1 | ++ | 2.1 |
| Pax8 | Paired box 8 | ++ | 3.9 | ++ | 2.2 |
| Cacna2d3 | Calcium channel, voltage-dependent, α2/δ3 | ++ | 2.5 | ++ | 2.1 |
| Pnoc | Prepronociceptin | ++ | 3.7 | ++ | 3.8 |
| Prkcq | Protein kinase Cθ | ++ | 3.9 | ++ | 2.4 |
| Npy | Neuropeptide Y | ++ | 5.6 | + | 1.5 |
| Neurod6 | Neurogenic differentiation 6 | ++ | 3.7 | + | 1.3 |
| Gad2 | Glutamic acid decarboxylase 2 | ++ | 3.6 | n.s. | |
| Nrxn3 | Neurexin III | ++ | 2.8 | + | 1.4 |
| Slc6a5 | Solute carrier family 6 member 5 | ++ | 3.4 | + | 1.4 |
| Grik2 | Glutamate receptor, ionotropic, kainate 2 (β2) | ++ | 2.3 | + | 1.6 |
| Klhl14 | Kelch-like 14 (Drosophila) | ++ | 2.6 | n.s. | |
| Rnf152 | Ring finger protein 152 | ++ | 1.8 | n.s. | |
| 6330527O06Rik | LAMP family protein C20orf103 homolog precur | ++ | 5.6 | + | 1.7 |
| Sall3 | Sal-like 3 (Drosophila) | ++ | 2.1 | + | 1.6 |
| Sez6 | Seizure-related gene 6 | ++ | 1.9 | + | 1.5 |
| 9230112E08Rik | RIKEN cDNA 9230112E08 gene | ++ | 1.5 | n.s. | |
| Xlr3a | X-linked lymphocyte-regulated 3A | ++ | 1.4 | n.s. | |
| Lhx1 | LIM homeobox protein 1 | ++ | 3.3 | n.s. | |
| Cadps2 | Ca2+-dependent activator protein for secretion 2 | ++ | 2.2 | n.s. | |
| Pax2 | Paired box gene 2 | ++ | 3.1 | n.s. | |
| Grik3 | Glutamate receptor, ionotropic, kainate 3 | ++ | 1.6 | n.s. | |
| Crabp1 | Cellular retinoic acid binding protein I | ++ | 1.5 | n.s. | |
| Mpped2 | Metallophosphoesterase domain containing 2 | ++ | 1.6 | n.s. | |
| Rorb | RAR-related orphan receptor β | ++ | 1.8 | + | 1.4 |
| Ipcef1 | Interaction protein for cytohesion exchange factors 1 | ++ | 1.5 | n.s. | |
| Tmem86b | Transmembrane protein 86B | ++ | 1.7 | n.s. | |
| Grm5 | Glutamate receptor, metabotropic 5 | ++ | 1.7 | + | 1.4 |
| Zmat4 | Zinc finger, matrin type 4 | ++ | 1.7 | + | 1.8 |
The transcriptome of dorsal horn cells of Ptf1a−/− and Ascl1−/− mice was compared with littermate controls using Affymetrix expression arrays. The gene symbol and name of the respective genes are depicted. In columns 3 and 5, it is indicated whether the downregulation of the respective gene was called highly significant (++, corrected p ≤ 0.005), significant (+, corrected p ≤ 0.05), or not significant (n.s.). In columns 4 (Ptf1a vs control) and 6 (Ascl1 vs control), the fold change (FC) the respective gene was downregulated according to the Affymetrix results is indicated.