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A proposed model for mononuclear phagocyte/microglia accumulation in Alzheimer’s disease highlighting the multiple steps involved in this process. Several chemokines that can recruit cells from the bone marrow → blood → brain → plaque may be involved. Distinct subsets of these chemokines and their receptors may act at one or more steps in this multistep process. The exact roles of these chemokines are only beginning to be elucidated.
