Figure 9. Representative time courses of whole-cell currents through mTRPA1-expressing CHO, measured at membrane potential of +50 mV (black curve) and −50 mV (grey curve) during administration of A) MO and ADM_09; B) Menthol and ADM_09; C) MO and HC030031; D) Menthol and HC030031 at the indicated concentrations and time intervals.

E) Dose-response curve for the inhibition of 100 μM MO-induced currents by ADM_09. The corresponding IC₅₀ value is 13.2 ± 0.5 μM. F) Dose-response curve for the inhibition of 100 μM menthol-induced currents by ADM_09. The corresponding IC₅₀ value is 10.3 ± 1.7 μM.