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Effect of BCRP on the vectorial transport of AR-67 in MDCKII-pcDNA/BCRP cells. Transepithelial transport of 5 µM AR-67 lactone in MDCKII-pcDNA and MDCKII-BCRP cells apical to basolateral (A > B; A and B) and basolateral to apical (B > A; C and D) in the presence (□) and absence (▿) of the inhibitor GF120918 (5 µM). AR-67 was quantified using HPLC as determined in the Materials and Methods section. Data are represented as the mean (n = 3) ± S.D.
