Fig. 6.

Stereoview of aligned Cα backbone of 11 solved CYP2B4 structures in the absence and presence of various ligands. This include structures with paroxetine (PDB ID 4JLT in blue), 4-CPI (PDB ID 1SUO in cyan), 1-CPI (PDB ID 2Q6N in brown), ligand free (PDB ID 3MVR in sky blue), ticlopidine (PDB ID 3KW4 in green), clopidogrel (PDB ID 3ME6 in magenta), tert-butylphenylacetylene (tBPA) (PDB ID 3R1A in yellow), L437A 4-CPI (PDB ID 3TK3 in yellow), amlodipine (PDB ID 3TMZ in red), F297A clopidogrel (PDB ID 4H1N in gray), and 9-ethynylphenanthrene (9-EP) (PDB ID 3UAS in light orange), as listed in Table 2. The helices F, F′, G′, G, B′, and β₁ and β₄ sheets involved in ligand access near channel 2f are labeled. The letters A, P, and C denote the 2B4 structures in complex with amlodipine, paroxetine, and 4-CPI, respectively.