Fig. 3.

Effect of Ca²⁺_e and the CaSR agonist calindol on relaxation of PE-contracted mesenteric arteries from C57BL/6 (A), nNOS^−/− (Β), and eNOS^−/− (C) mice mounted in PSS with 1 mM CaCl₂. Responses of precontracted arteries to 1 mM Ca²⁺ and calindol (1 and 10 μM) are shown. (D) Relaxations of precontracted arteries to Ca²⁺ and calindol. (E) Relaxations of isolated, precontracted arteries from C57BL/6 mice to Ca²⁺, calindol, and the calcilytic Calhex 231. Values plotted are means (± S.E.) of 4–6 animals. *P < 0.05 vs. C57BL/6 and nNOS^−/−; ^#P < 0.05 vs. C57BL/6 and eNOS^−/−; **P < 0.05 vs. calindol responses (analysis of variance).