TABLE 1.

EC₅₀ values for Ca²⁺_e-induced relaxation of PE-contracted mesenteric arteries in the absence (Control) and presence of IbTX (100 nM) or of NOS inhibitors (10 μM each)

Values are means (± S.E.M.) derived from data fitted to a standard four-parameter sigmoid curve in the pharmacology menu of the SigmaPlot 11.0 program. The number of animals for each group is indicated.

Group	EC50 Values in Presence of:
	Control	IbTX	l-NIO	l-NAME	l-NMMA	S-MeTC	7-NI
	mM
C57BL/6	2.0 ± 0.1 (n = 15)	1.9 ± 0.2 (n = 7)	3.4 ± 0.3* (n = 4)	2.0 ± 0.1 (n = 5)	1.8 ± 0.1 (n = 5)	3.6 ± 0.5* (n = 5)	1.8 ± 0.2 (n = 6)
nNOS−/−	2.0 ± 0.1 (n = 13)	3.2 ± 0.3¶ (n = 5)	2.3 ± 0.7¶ (n = 4)	2.8 ± 0.4 (n = 4)	2.3 ± 0.1 (n = 4)	1.7 ± 0.2¶ (n = 4)	2.0 ± 0.1 (n = 4)
eNOS−/−	2.0 ± 0.1 (n = 20)	4.4 ± 0.8¶ (n = 5)	2.2 ± 0.1¶ (n = 7)	2.1 ± 0.1 (n = 4)	2.1 ± 0.1 (n = 4)	2.6 ± 0.1¶ (n = 8)	1.8 ± 0.1 (n = 6)

^*P < 0.05 vs. Control; ^¶P < 0.05 vs. C57BL/6.