Fig. 2.

Antihyperalgesic effects of intrathecal administration of SCH221510 and morphine in mice with inflammatory pain. Effects of SCH221510 (A) and morphine (C) on paw withdrawal latencies (sec). Percentage of maximum possible effect of SCH221510 (B) and morphine (D) for attenuating thermal hyperalgesia. BL, baseline values before induction of paw inflammation. Pre-, predrug values before intrathecal administration of drugs. Behavioral responses were measured at 0.5, 1, 2, 3, 4, 24, and 48 hours after drug administration. Each value represents the mean ± S.E.M. (n = 6). Symbols represent different dosing conditions in different groups of mice. *Statistically significant difference from the vehicle controls (○, 0 μg) (P < 0.05).