Fig. 3.

Antiallodynic effects of intrathecal administration of BU08028, SR16435, and buprenorphine in mice with neuropathic pain. Effects of BU08028 (A), SR16435 (C), and buprenorphine (E) on paw withdrawal thresholds (g). Percentage of maximum possible effect of BU08028 (B), SR16435 (D), and buprenorphine (F) for attenuating tactile allodynia. BL, baseline values before induction of nerve injury. Pre-, predrug values before intrathecal administration of drugs. Behavioral responses were measured at 0.5, 1, 2, 3, 4, 24, and 48 hours after drug administration. Each value represents the mean ± S.E.M. (n = 8). Symbols represent different dosing conditions in different groups of mice. *Statistically significant difference from the vehicle controls (○, 0 μg) (P < 0.05).