Fig. 4.

Antihyperalgesic effects of intrathecal administration of BU08028, SR16435, and buprenorphine in mice with inflammatory pain. Effects of BU08028 (A), SR16435 (C), and buprenorphine (E) on paw withdrawal latencies (sec). The % maximum possible effect of BU08028 (B), SR16435 (D), and buprenorphine (F) for attenuating thermal hyperalgesia. BL, baseline values before induction of paw inflammation. Pre-, predrug values before intrathecal administration of drugs. Behavioral responses were measured at 0.5, 1, 2, 3, 4, 24, and 48 hours after drug administration. Each value represents the mean ± S.E.M. (n = 8). Symbols represent different dosing conditions in different groups of mice. *Statistically significant difference from the vehicle controls (○, 0 μg) (P < 0.05).