Fig. 4. A proposed model for the inhibition of hIAPP fibrillization by FGAΔFL/FGAΔFI. (a) Unfolded state of hIAPP; (b) monomeric helical form of hIAPP (2KB8); (c) 3D structure of the inhibitor FGAΔFL, stick and surface representations; (d) inhibitor computationally docked with hIAPP; complex structure. The binding of inhibitors to hIAPP is expected to discourage the formation of toxic oligomers/fibrils (e), which in the final stage of aggregation result in amyloid plaques (f).
