Table 3.
Association of EREG Polymorphism rs7675690 with Mtb Bacterial Strain Type
| Group | AA/AG/GG | Allelic ORa (95%CI) | P-value | Genotypic P-value |
Recessive Model (AA+AG vs GG)
|
|
|---|---|---|---|---|---|---|
| OR (95%CI) | P-value | |||||
| Controls | 306/55/4 | |||||
| All TB | ||||||
| All isolates | 231/16/14 | 0.97 (0.65–1.46) | 0.9 | 3.0 × 10−5 | 5.11 (1.66–15.72) | 0.002 |
| Non-Beijing | 138/5/5 | 0.56 (0.32–1.01) | 0.051 | 0.0003 | 3.13 (0.84–11.92) | 0.074 |
| Beijing | 93/11/9 | 1.56 (0.98–2.49) | 0.061 | 0.0002 | 7.81 (2.36–25.86) | 8.7 × 10−5 |
| PTB | ||||||
| All isolates | 126/9/4 | 0.69 (0.40–1.20) | 0.187 | 0.015 | 2.67 (0.66–10.84) | 0.153 |
| Non-Beijing | 78/3/1 | 0.33 (0.13–0.84) | 0.015 | 0.021 | 1.11 (0.12–10.10) | 0.923 |
| Beijing | 48/6/3 | 1.25 (0.65–2.39) | 0.508 | 0.053 | 5.01 (1.09–23.02) | 0.022 |
| TBM | ||||||
| All isolates | 105/7/10 | 1.32 (0.82–2.12) | 0.255 | 1.4 × 10−5 | 8.06 (2.48–26.19) | 4.8 × 10−5 |
| Non-beijing | 60/2/4 | 0.87 (0.43–1.74) | 0.689 | 0.001 | 5.82 (1.42–23.89) | 0.006 |
| Beijing | 45/5/6 | 1.89 (1.06–3.37) | 0.028 | 4.0 × 10−5 | 10.83 (2.95–39.71) | 1.1 × 10−5 |
Abbreviations: CI, confidence interval; EREG, epiregulin; OR, odds ratio, Mtb, Mycobacterium tuberculosis.
a
For OR calculation the genotype distribution in each group was compared with the control group.