Figure 1. 5′-AMP-induced torpor results in the reversible reduction in the number of circulating T and B lymphocytes as a result of the activation of A2BR and independently of changes in body temperature.
Body temperature of mice prior to and following torpor induction by 5′-AMP (7.5 mmol/kg) or injection of the A2b agonist LUF6210 (3 mg/kg; A). The number of circulating total lymphocytes (B), T lymphocytes (C), or B lymphocytes (D) in mice at the indicated time following administration of 5′-AMP, the specific A2BR antagonist MRS1754 (12.5 mg/kg), and/or the A2b agonist LUF6210. Bars represent mean ± sem; */** = P < 0.05/0.01, respectively (n=6–9 animals/group).