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. 2013 Jul;94(1):89–98. doi: 10.1189/jlb.1212613

Figure 4. Restoration of lymphocyte counts during return to euthermia after torpor requires lymphocyte egress from secondary lymphoid organs.

Figure 4.

Plasma S1P levels in mice prior to (0 h), 4 h, or 10 h following torpor induction with 5′-AMP (7.5 mmol/kg) or at 4 h after administration of the A2BR agonist LUF6210 (3 mg/kg; A). Peripheral blood lymphocyte counts (B), T lymphocyte counts (C), and B lymphocyte counts (D) in mice during torpor (4 h post-5′-AMP administration) or following return to euthermia in mice (10 h post-5′-AMP administration) that were given the S1P1-specific antagonist W146 (10 mg/kg) compared with untreated controls. Bars represent mean ± sem; */** = P < 0.05/0.01, respectively (n=6–9 animals/group).