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. 2013 Jul;94(1):89–98. doi: 10.1189/jlb.1212613

Figure 5. 5′-AMP-induced torpor reduces lymphocyte recirculation rates and causes retention of lymphocytes in secondary lymphoid organs.

Figure 5.

LN homing of lymphocytes was blocked by the administration of anti-α4- and anti-αL-integrin antibodies, 2 h prior to 5′-AMP (7.5 mmol/kg) or saline injection and the number of total lymphocytes (A), T lymphocytes (B), or B lymphocytes (C) measured in the peripheral blood. To assess the change in homing efficiency of T cells during torpor, congenic CD45.1+ T cells were adoptively transferred to recipients given 5′-AMP and the number of CD45.1+ cells counted, 2 h post-transfer in inguinal (iLN), axillary (aLN), and mesenteric (mLN) LNs; the homing efficiency of adoptively transferred T cells is shown as the percent of cells relative to saline controls (D). Bars represent mean ± sem; */** = P < 0.05/0.01, respectively (n=4–6 animals/group).