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. 2013 Jul;94(1):171–182. doi: 10.1189/jlb.1212659

Figure 2. Cerebella of TLR4-deficient, alcohol-fed mice are partially protected against inflammatory cytokine production.

Figure 2.

WT (n=8 or 7) and TLR4-KO (n=8 or 13) mice were fed with a control (PF) or EtOH diet for 5 weeks, respectively. Inflammatory cytokines, TNF-α (A), MCP-1 (B), and IL-1β (C) of whole cerebellar lysates, were measured by specific ELISAs. Endotoxin measurement was executed in serum and whole cerebellar lysates of WT mice by LAL assay (D). Bars represent mean ± sem (*P<0.05, relative to appropriate PF or WT-EtOH controls; #P<0.05, relative to appropriate WT-PF controls by the Kruskal-Wallis nonparametric test).