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. Author manuscript; available in PMC: 2013 Jun 18.
Published in final edited form as: Curr Opin Gastroenterol. 2012 Mar;28(2):89–98. doi: 10.1097/MOG.0b013e32835004c6

Figure 3. Schematic of structure, ligand binding affinity and putative roles of IGF1R and insulin receptor (IR) isoforms (IR-A and IR-B).

Figure 3

High sequence homology allows all three receptors to bind IGF1, IGF2, and insulin, but with differing affinities, indicated by gradients. IR-A and IR-B differ by inclusion of exon 11 (E11) only in IR-B. Different ligand binding affinities and downstream signaling intermediates, confer the different functional outcomes indicated. For small intestine these are still putative outcomes since neither expression patterns nor specific functions of IGF1R, IR-A and IR-B are defined.