Table 1.
Formal Search Results Showing the Best HLA-Matched URD or Best CB Units in Patients who Underwent Combined Searches (n = 525): URD Predominantly Serves Patients of North-western, Eastern, or Mixed European Ancestry, Whereas CB Extended Access to a Stem Cell Source to Both Europeans and Non-Europeans.
| Patients of European Ancestries | ||||
|---|---|---|---|---|
| North-western European (n = 104) | Eastern European (n = 76) | Southern European (N = 60) | European Mix (n = 101) | |
| Best URD | ||||
| 10/10 | 64 (62%) | 45 (59%) | 20 (33%) | 51 (50%) |
| 9/10 | 28 (27%) | 20 (26%) | 20 (33%) | 31 (31%) |
| ≤ 8/10 | 12 (12%) | 11 (14%) | 20 (33%) | 19 (19%) |
| Best CB* | ||||
| 5–6/6 | 88 (85%) | 62 (82%) | 36 (60%) | 84 (83%) |
| 4/6 | 15 (14%) | 12 (16%) | 15 (25%) | 14 (14%) |
| No CB | 1 (1%) | 2 (3%) | 9 (15%) | 3 (3%) |
| Patients of Non-European Ancestries | |||||
|---|---|---|---|---|---|
| Asian (n = 42) | African (n = 61) | White Hispanic (n = 48) | Middle Eastern (n = 10) | Non-European Mix (n = 23) | |
| Best URD | |||||
| 10/10 | 8 (19%) | 5 (8%) | 10 (21%) | 6 (60%) | 9 (39%) |
| 9/10 | 6 (14%) | 20 (33%) | 14 (29%) | 1 (10%) | 8 (35%) |
| ≤ 8/10 | 28 (67%) | 36 (59%) | 24 (50%) | 3 (30%) | 6 (26%) |
| Best CB* | |||||
| 5–6/6 | 36 (86%) | 35 (57%) | 33 (69%) | 8 (80%) | 19 (83%) |
| 4/6 | 6 (14%) | 14 (23%) | 10 (21%) | 2 (20%) | 2 (9%) |
| No CB | 0 | 12 (20%) | 5 (10%) | 0 | 2 (9%) |
*
Best CB units were defined according to HLA-match but also had to have an adequate TNC dose of at least 1.5 × 107/kg/unit.