. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Feb 28;33(5):1092–1097. doi: 10.1161/ATVBAHA.112.301089

Table 2.

Relative Risks (95% Confidence Intervals) of Lower Extremity Peripheral Artery Disease According to Total Adiponectin

	Continuous Adiponectin (per Each SD Increase in ln-Transformed Variable)	Quartile of Adiponectin, Median (Range), μg/mL
		2.84 (1.54-3.62)	4.28 (3.63-5.05)	5.98 (5.06-7.16)	9.02 (7.17-31.9)	P _trend
Cases, n	143	53	44	27	19
Controls, n	429	90	99	116	124
Matching variables	0.58 (0.47-0.72)	1.00 (Reference)	0.73 (0.45-1.19)	0.39 (0.23-0.66)	0.24 (0.13-0.44)	<0.0001
Multivariable model 1	0.58 (0.45-0.74)	1.00 (Reference)	0.62 (0.35-1.10)	0.43 (0.24-0.79)	0.20 (0.10-0.42)	<0.0001
Multivariable model 2	0.68 (0.51-0.92)	1.00 (Reference)	0.47 (0.24-0.91)	0.52 (0.27-1.00)	0.28 (0.12-0.67)	0.005
Multivariable model 3	0.68 (0.50-0.92)	1.00 (Reference)	0.48 (0.25-0.94)	0.55 (0.28-1.08)	0.28 (0.12-0.66)	0.006

Relative risks are derived from conditional logistic regression models. Matching variables were age, smoking status, fasting status and date of blood draw. P_trend is calculated by treating the median of natural log-transformed adiponectin concentrations of each quartile as a continuous variable. Multivariable model 1 is adjusted for pack-years of smoking, history of type 2 diabetes, history of hypertension, history of hypercholesterolemia, parental history of myocardial infarction before age 60 y, body mass index and physical activity. Multivariable model 2 is model 1 + high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein and cystatin C. Multivariable model 3 is model 2 + hemoglobin A_1c, triglycerides and gamma-glutamyltransferase.