Table 3. Top 20 Most Promiscuous Assaysa.
| AC50s |
||||
|---|---|---|---|---|
| assay target | assay category | total | ≤10 μM | ≤1 μM |
| hCYP2C19 | CYP | 264 | 144 | 53 |
| hCYP2C9 | CYP | 152 | 81 | 19 |
| rPBR | transporter | 147 | 62 | 18 |
| hPXR | nuclear receptor (subfamily 1) | 140 | 73 | 35 |
| hNET | transporter | 136 | 48 | 13 |
| hPBR | transporter | 117 | 36 | 5 |
| hDAT | transporter | 117 | 45 | 7 |
| hCYP1A2 | CYP | 108 | 60 | 16 |
| gDAT | transporter | 98 | 26 | 4 |
| h5HT7 | GPCR (aminergic) | 96 | 35 | 13 |
| hGR | nuclear receptor (subfamily 3) | 96 | 35 | 6 |
| hOpiate_mu | GPCR (other) | 92 | 27 | 5 |
| hDRD1 | GPCR (aminergic) | 89 | 36 | 9 |
| rNaCh_site2 | ion channel | 87 | 37 | 13 |
| hCYP2B6 | CYP | 81 | 43 | 16 |
| gSIGMA_NonSelective | other | 80 | 31 | 13 |
| gOpiateK | GPCR (other) | 75 | 18 | 4 |
| rMAOAC | other enzyme | 73 | 15 | 6 |
| hAR | nuclear receptor (subfamily 3) | 73 | 33 | 8 |
| hBACE | protease | 73 | 28 | 3 |
a
Columns indicate the topmost promiscuous assay targets (corresponding to one assay), the respective assay category, the total number of calculated AC50s, and the number of AC50s affecting the assay at ≤10 μM and ≤1 μM. The number of AC50s corresponds to the number of chemicals affecting a given assay at the AC50 value constraint.