Table 6. Assay–Assay Similaritiesa.
| clustersb | assay categoriesc | assay targets |
|---|---|---|
| Cluster i (22) | ||
| subcluster1 | GPCR (other) (4) | rmMGluR5, rVIP (nonselective), hETB, bAT2 |
| subcluster2 | GPCR (other) (2) | hNPY2, bNPY (nonselective) |
| Cluster ii (52) | ||
| subcluster1 | GPCR (aminergic) (18) | hH1, gH2, hM1–5, gMperipheral, rAdra1A&B, rAdra1&2(nonselective), hAdra2A, rmAdra2B, hAdrb2, r5HT(nonselective), h5HT2A, bDR(nonselective) |
| GPCR (other) (3) | gOpiateK, rOpiate Non-Selective | |
| ion channel (2) | rNaCh, rCaBTZCHL | |
| subcluster2 | GPCR (aminergic) (7) | hDRD1, hDRD2s, hDRD4.4, h5HT5A, h5HT7, hAdra2C, hAdrb1 |
| GPCR (other) (2) | hOpiateD1 & Mu | |
| Cluster iii (41) | ||
| subcluster1 | activator: kinase (4) | hNEK2, hFyn, hIGF1R, hSRC |
| kinase (3) | hMAPKAP2, hMAPK3, hPAK4 | |
| activator: phosphatase (1) | hPPM1A | |
| phosphatase (4) | hPTPN4, 9, 14, hACP1 | |
| subcluster2 | kinase (9) | hRAF1, hCSF1R, hEGFR, hMAPK1, hTie2, hMsk1, hVEGFR2&3, hAurA |
| phosphatase (7) | hPTPN1, 2, 6, 11, 12, hPTPRB, hPTEN | |
a
Three clusters were identified through assay similarity analysis for further analysis.
b
Subclusters were identified from clusters along the diagonal with ≥65% similarity. Numbers in parentheses indicate the number of assays within a cluster.
c
Numbers in parentheses indicate the number of assays within an assay category.