Figure 6.
(A) The effects of VE, TS, TPD and TPGS on P-gp ATPase. Na3VO4 (sodium orthovanadate), which is contained in the assay kit, is a selective inhibitor of P-gp. * indicates a significant difference from the control, p <0.05. (B) The effects of TPGS, VE and its derivatives on Verapamil induced ATPase activity. * indicates a significant difference from verapamil, p <0.05, ** indicates a highly significant difference compared to PTX (in DMSO), p <0.01. VE, TS, TPD and TPGS were administered in an amount of 50 μM. Data are represented as the mean ± SD (n=5).
