Table 2.
Between-group effects for face conditions
| MNI coordinates
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Analysis | BA | Region | Voxels | Side | x | y | z | T | F | Z value | p uncorrected | p FWE corrected | Effect |
| Activity to all faces (emotion and identity) versus shapes | |||||||||||||
| Across groups, all participants: testing hypothesis 1 a | |||||||||||||
| Whole brain | 37 | Fusiform gyrus | 2970 | R | 40 | −60 | −18 | – | 177.11 | >8 | <0.001 | <0.001 | – |
| 18 | Inferior occipital | 1989 | L | −34 | −84 | −12 | – | 131.74 | >8 | <0.001 | <0.001 | – | |
| Amygdala | 535 | R | 20 | −6 | −16 | – | 44.02 | 5.93 | <0.001 | <0.001 | – | ||
| Amygdala | 415 | L | −18 | −6 | −14 | – | 38.70 | 5.6 | <0.001 | 0.001 | – | ||
| Lingual gyrus | 180 | L | −18 | −46 | −2 | – | 28.90 | 4.9 | <0.001 | 0.02 | – | ||
| Between-group differences: testing hypothesis 1b | |||||||||||||
| Main effect of group | |||||||||||||
| Whole brain | 21 | Superior temporal gyrus | 86 | R | 62 | −12 | −2 | – | 25.19 | 4.6 | <0.001 | 0.086 | |
| Amygdala ROI | Amygdala | 151 | R | 18 | −8 | −14 | – | 10.35 | 2.92 | 0.002 | 0.07 | ||
| Between-group differences in neural activity for the face processing conditions | |||||||||||||
| Interaction of group by face condition | |||||||||||||
| Whole brain | 4 | Somatosensory cortex | 1217 | R | 32 | −20 | 50 | – | 32.63 | 5.19 | <0.001 | 0.006 | Emotion condition with bipolar activating, controls deactivating |
| Amygdala ROI | Amygdala | 113 | L | −28 | 0 | −18 | – | 12.13 | 3.18 | 0.001 | 0.03 | Emotion condition with bipolar activating >controls | |
| Face emotion minus shape: testing hypothesis 2 | |||||||||||||
| Whole brain | 4 | Somatosensory cortex | 660 | R | 32 | −22 | 48 | 5.25 | – | 4.68 | <0.001 | 0.06 | BDe >HC |
| Amygdala ROI | Amygdala | 153 | R | 18 | −6 | −18 | 3.17 | – | 3.02 | 0.001 | 0.04 | BDe >HC | |
| Face identity minus shape: testing hypothesis 3 | |||||||||||||
| Whole brain | 9 | Medial frontal gyrus | 88 | R | 18 | 40 | 22 | 5.30 | – | 4.72 | <0.001 | 0.05 | BDe >HC |
| Amygdala ROI | Amygdala | 92 | R | 20 | −8 | −14 | 3.08 | – | 2.94 | 0.002 | 0.05 | BDe >HC | |
| Individual face emotion condition | |||||||||||||
| Angry | |||||||||||||
| Whole brain | N.A. | – | – | – | – | – | – | – | – | – | – | ||
| Amygdala ROI | N.A. | – | – | – | – | – | – | – | – | – | – | ||
| Fear | |||||||||||||
| Whole brain | 38 | Superior temporal gyrus | 163 | R | 36 | 8 | −20 | 4.89 | <0.001 | 0.02 | BDe >HC | ||
| Amygdala ROI | N.A. | – | – | – | – | – | – | – | – | – | – | ||
| Sad | |||||||||||||
| Whole brain | N.A. | – | – | – | – | – | – | – | – | – | – | ||
| Amygdala ROI | – | Amygdala | 49 | L | −24 | −4 | −26 | 2.96 | 0.002 | 0.04 | BDe >HC | ||
| Happy | |||||||||||||
| Whole brain | 24 | Medial frontal gyrus | 452 | L | −12 | 24 | 28 | 4.61 | <0.001 | 0.05 | BDe >HC | ||
| Amygdala ROI | – | Amygdala | 138 | R | 28 | −2 | −16 | 3.16 | 0.001 | 0.02 | BDe >HC | ||
BA, Brodmann Area; FWE, family-wise error correction for multiple comparisons at the peak voxel; FDR, false detection rate correction for multiple comparisons at the peak voxel; MNI, Montreal Neurologic Institute; ROI, region of interest; BDe, bipolar disorder currently euthymic; HC, healthy controls; N.A., not applicable; L, left; R, right.