Survival of mice with ID8 or SW1 tumors. Mice transplanted i.p. with 3×106 ID8 cells 10 (10 mice/group, Panel a) or 15 (5 mice/group, Panel b) days previously were injected i.p. with the indicated mAbs; mAb injections were repeated as shown by arrows. Panel c depicts the survival of mice with SW1 tumors (9 mice/group); arrows show when the mAbs were injected. Panel d shows tumor growth curves for individual mice from the SW1 experiment in Panel c; numbers in parentheses indicate the fraction of tumor-free mice at 140 days post first therapy. Panel e depicts an experiment in which 5 mice whose SW1 tumors had completely regressed were transplanted s.c. with 5×106 SW1 cells and followed for tumor growth, as were 5 age matched naïve mice. * p<0.05, **p<0.01, *** p<0.001.