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. Author manuscript; available in PMC: 2014 May 22.
Published in final edited form as: J Am Chem Soc. 2013 May 8;135(20):7567–7571. doi: 10.1021/ja400659s

Table 3.

meta-Olefination of 2-Bromo-Phenol Derivativesa,b,c

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a

Reaction conditions: 4p (0.1 mmol), 2a–2f (0.2 mmol), Pd(OAc)2 (10 mol %), Ac-Gly-OH (20 mol %), AgOAc (0.3 mmol), HFIP (1 mL), 90 °C, 24h.

b

Isolated yield.

c

Regioselectivity were determined by 1H NMR analysis of the crude product and confirmed by one-dimensional selective NOESY experiments; the variance is estimated to be within 5%.