Table 3.

Longitudinal samples used for the independent validation of the HRNB classifier.

Pt No.	Pt Info	Time Point	Disease Status	Sites of Disease	Prediction	Correct?
1	M, 12 mo, MNA
		Diagnosis	Present	ST, B, BM	Disease	Yes
		On Therapy	Present	ST, B	Disease	Yes
		Progression	Present	ST, B, BM	Disease	Yes
		On Therapy	Not Present		Disease	No
		Relapse	Present	ST, B, BM	Disease	Yes
2	F, 12 mo, MNA
		Diagnosis	Present	ST, B, BM	Disease	Yes
		On Therapy	Present	ST, B, BM	Disease	Yes
		On Therapy	Not Present		No Disease	Yes
		Off Therapy	Not Present		No Disease	Yes
3	F, 52 mo, MA
		Diagnosis	Present	ST, B	Disease	Yes
		On Therapy	Not Present		No Disease	Yes
		On Therapy	Not Present		No Disease	Yes
4	M, 24 mo, MA
		Diagnosis	Present	ST1	Disease	Yes
		On Therapy	Not Present		No Disease	Yes
		On Therapy	Not Present		No Disease	Yes
		Off Therapy	Not Present		No Disease	Yes
5	F, 22 mo, MA
		Diagnosis	Present	ST1	Disease	Yes
		Relapse	Present	ST	Disease	Yes
		Progression	Present	ST, B, BM	Disease	Yes
6	M, 14 mo, MA
		Diagnosis	Present	ST, B2	No Disease	No
		On Therapy	Not Present		No Disease	Yes
		On Therapy	Not Present		No Disease	Yes
		Off Therapy	Not Present		Disease	No
7	M, 55 mo, MA
		Diagnosis	Present	ST, B, BM	Disease	Yes
		On Therapy	Present	ST, B, BM	Disease	Yes
		On Therapy	Present	ST, BM	Disease	Yes
		On Therapy	Present	BM	Disease	Yes
		On Therapy	Present	ST, BM	No Disease	No

Pt info: M=male, F=female; mo=age in months at diagnosis; MA=MYCN amplified; MNA=MYCN not amplified. Sites of Disease: ST=soft tissue; B=Bone; BM=Bone Marrow.

¹Stage 3

²No Primary Tumor.