Table 1. DAP12-associated receptors.
| Name | Species | Cell expression | Expression in osteoclast | Ligands |
|---|---|---|---|---|
| KIR2DS1, KIR2DS2, KIR2DS3 | Human | NK cells, T-cell subsets | ? | HLA class I (KIR2DS1) |
| CD94-NKG2C, CD94-NKG2E | Human, mouse | NK cells, T-cell subsets | ? | HLA-E (human), Qa-1b (mouse) |
| Ly49Db6a, Ly49Hb6, Ly49R129/J, Ly49U129/J | Mouse | NK cells, T-cell subsets | ? | H-2Dd, M157 (CMV protein) |
| NKG2D-Sa (short isoform) | Mouse | NK cells, T-cell subsets, macrophages | + | Rae-1, H60, Mult I |
| NKp44 | Human | NK cells, γδ T cells, pDCs | ? | Viral HA? PCNA, proliferating cell nuclear antigen |
| TREM1, TREM3b | Human, mouse | Monocyte, neutrophils, macrophages, osteosteoclasts | TREM3 +by RTPCR | |
| TREM2a | Human, mouse | Macrophages, DCs, mast cells, osteoclasts, microglia | + | Anionic ligands (dextran slufate and bacteria), HSP60, apoptotic membranes |
| TLT4 | Mouse | ? | ||
| MDL1a | Human, mouse | Monocytes, macrophages, DCs | + | Dengue virion |
| SIRPβ | Human, mouse | Neutrophils, monocytes, macrophages, DCs | + | |
| CD300C, CD300Db, CD300Eb | Human, mouse | Myeloid cells | ? | |
| CD200R3, CD200R4 | Human, mouse | Myeloid cells | + | CD200 |
| PILRβ | Human, mouse | Leukocytes, NK cells, macrophages, neutrophils, DCs | + | PILR-β ligand (CD99-like), sialylated O-linked sugars |
| SIGLEC-H | Mouse | pDCs | ? | |
| SIGLEC14 |
Human, mouse |
Hematopoietic cells |
? |
A2-8-linked oligo Neu5A |
Abbreviations: DCs, dendritic cells; NK cells, natural killer cells; PCNA, proliferating cell nuclear antigen; pDC, plasmacytoid dendritic cell.
aIndicates receptor can also associate with DAP10.
bIndicates receptor is in mouse only.+ Indicates expression in osteoclasts.? Indicates osteoclast expression unknown.