Table 1.
Basic membrane properties and action potential characteristics of neurons in the VTA
| Vm (mv) | Firing rate (Hz) | AP threshold (mV) | AP duration (ms) | AHP peak (mV) | AHP time to peak (ms) | AHP at 50 ms (mV) | |
|---|---|---|---|---|---|---|---|
| Medial glut | −59.6 ± 1.6* | 3.7 ± 0.8 | −41.3 ± 0.9* | 2.6 ± 0.2* | −68.6 ± 2.0* | 15.4 ± 3.2 | −62.2 ± 1.2 |
| Medial DA | −54.7 ± 1.3 | 2.9 ± 0.4 | −38.1 ± 0.9 | 3.3 ± 0.2 | −62.5 ± 1.7 | 19.0 ± 2.2 | −58.6 ± 1.6 |
| Lateral DA | −56.8 ± 0.9 | 1.1 ± 0.3** | −41.7 ± 1.0* | 2.8 ± 0.1 | −73.1 ± 1.8*** | 28.2 ± 5.2 | −71.7 ± 1.9*** |
Statistically significant difference relative to medial dopamine neurons, two-tailed t test, *p < 0.05,
**p < 0.01,
***p < 0.001. Vm, initial membrane potential; AP, action potential; AHP, afterhyperpolarization.