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. 2013 May 23;41(Pt 3):727–740. doi: 10.1042/BST20130028

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© 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) The CFP1 DNA-binding tripeptide IRQ (Ile-Arg-Gln) forms both side-chain and backbone hydrogen bonds with the CpG dinucleotide (CpG from one DNA strand and C'pG' from the other). Base-pairing hydrogen bonds are shown by black broken lines and ZF-CxxC tripeptide–DNA hydrogen bonds are shown as red broken lines. (B) As in (A), with methyl groups (me) at the 5 position of the cytosine rings. Cytosine methylation causes steric clash with the CFP1 tripeptide. (C) The TET1 DNA-binding tripeptide SHQ (Ser-His-Gln) forms both side-chain and backbone hydrogen bonds with the CpG dinucleotide as in (A). (D) DNA methylation of a CpCpG-containing substrate causes TET1 to shift binding 1 bp along the DNA to interact with the non-methylated cytosine.