Table II.
Characteristics of menstrual cycles according to the mean serum uric acid levels.
| Mean serum uric acid (tertiles)a |
P-valueb | ||||
|---|---|---|---|---|---|
| Total cohort | Low (UA ≤3.83 mg/dl) | Medium (3.83 mg/dl <UA, ≤4.44 mg/dl) | High (UA >4.44 mg/dl) | ||
| n (number of cycles)c | 509 | 171 | 173 | 165 | |
| Anovulatoryd | 42 (8.3) | 8 (4.7) | 11 (6.4) | 23 (14.0) | 0.007 |
| Cycle length, days | 28.8 ± 4.1 | 28.4 ± 4.1 | 29.1 ± 3.7 | 28.9 ± 4.5 | 0.32 |
| Luteal phase length, days | 13.9 ± 2.4 | 13.8 ± 1.7 | 14.2 ± 2.3 | 13.9 ± 3.0 | 0.31 |
| Luteal phase <12 d, n (%) | 41 (9.3) | 10 (6.4) | 13 (8.3) | 18 (13.7) | 0.11 |
| Uric acid (mg/dl) levels for luteal phase <12 days | 4.35 ± 0.64 | 3.51 ± 0.31 | 4.18 ± 0.18 | 4.93 ± 0.30 | 0.97 |
| Uric acid (mg/dl) levels for luteal phase ≥12 days | 4.08 ± 0.65 | 3.44 ± 0.35 | 4.10 ± 0.18 | 4.88 ± 0.36 | |
| Mean estradiole (pg/ml) | 112.0 ± 43.4 | 114.0 ± 41.4 | 116.4 ± 44.5 | 105.4 ± 43.6 | 0.05 |
| Mean progesterone (ng/ml) | 3.4 ± 1.8 | 3.7 ± 1.7 | 3.6 ± 1.7 | 3.0 ± 1.8 | 0.0004 |
| Mean LH (ng/ml) | 9.5 ± 3.6 | 9.1 ± 3.5 | 9.7 ± 3.6 | 9.8 ± 3.8 | 0.21 |
| Mean FSH (mIU/ml) | 6.4 ± 2.4 | 6.7 ± 2.8 | 6.2 ± 1.8 | 6.3 ± 2.4 | 0.09 |
aWomen were categorized according to tertile of mean uric acid levels across all 16 study visits.
bTwo-sided P-values for continuous variables calculated using repeated measures ANOVA, and for categorical variables using Fisher's exact test. All comparisons take repeated measures and correlations between cycles into account.
c250 women in the BioCycle study were followed for two cycles, nine women were followed for one cycle, for a total of 509 cycles.
dTwenty-eight women in the study had only one anovulatory cycle, and seven women in the study had two anovulatory cycles for a total of 35 women with at least one anovulatory cycle. There were a total of 42 anovulatory cycles out of a total 509 in the BioCycle study.
eIndicates the mean of the within-woman average of all hormone measurements.