Table 2.
Notch receptors and Notch ligands | Type of gastric cancer | The role of Notch proteins in gastric cancer pathogenesis |
---|---|---|
Notch1 | premalignant and cancer tissue: intestinal metaplasia and well differentiated intestinal type of gastric cancer | crucial role in promoting metaplastic transition of gastric epithelial cells and in maintaining constant proliferation of intestinalized epithelial cells |
Notch2 | intestinal and diffuse type | – |
DLL1 | diffuse and mixed type | – |
Notch3 Jagged | intestinal type | – |