Figure 3. Structural location of the conserved motifs.

The Hepatitis C virus helicase (in green color) is structurally superposed over the Classical Swine Fever virus helicase model (colored in Red). The major motifs have been color-coded according to the conventions of Fig. 1, and are showing in space filling representation. The ssRNA oligonucleotide is showing in blue ribbon representation. The white arrow point to the ATP site of the helicase. Notably, the conserved motifs sit around the ATP site, where they coordinate the ATP hydrolysis by the helicase enzyme.