TC-10600 reduced L-dopa-induced AIMs. The treatment regimen with TC-10600 is depicted in the upper panel. All rats were unilaterally lesioned with 6-OHDA, next pretreated with TC-10600 (1.0 mg/kg/d) for 2 wk via minipump and then injected with L-dopa plus benserazide (8 mg/kg plus 15 mg/kg sc). After several wk at 1.0 mg/kg/d TC-10600, the initial minipump was replaced with one releasing 1.8 mg/kg/d. The rats were assessed for axial, oral, and forelimb AIMs as indicated in the timeline, with the total AIMs being the sum of these three components. The daily time course of the total L-dopa-induced AIMs is shown in the graphs at the right. Values are the mean ± S.E.M. of 7–9 rats per group. Significance of difference from vehicle: *p < 0.05.