TABLE 2.

Effect of the 6-OHDA lesion on α6β2^* nAChRs and α4β2^* nAChRs in rat striatum. ¹²⁵I-Epibatidine binding in the presence of the α6β2^* nAChR antagonist α-CtxMII was used to identify α4β2^* nAChRs, while ¹²⁵I-α-CtxMII was used to detect α6β2^* nAChRs in striatum. The concentrations of ¹²⁵I-α-CtxMII and ¹²⁵I-epibatidine were 0.5 nM and 0.015 nM, respectively. Values represent the mean ± SEM of 8 rats 6-OHDA-lesioned rats not treated with nAChR drugs.

nAChRs	fmol/mg tissue		% Control
	Unlesioned side	Lesioned side
α6β2*	3.45 ± 0.13	0.10 ± 0.01***	2.9
α4β2*	6.86 ± 0.23	6.08 ± 0.03*	88

Significance of difference from unlesioned side:

^*p < 0.05,

^***p < 0.001.