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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Neuropharmacology. 2013 Apr 12;71:191–203. doi: 10.1016/j.neuropharm.2013.03.038

TABLE 5.

EC50 and Rmax values for compound-evoked 3H-dopamine release from rat striatum. Rat striatal synaptosomes were exposed to the nAChR compounds to evoke 3H-dopamine release. Release is expressed as the % release relative to that occurring with 10 μM nicotine. For the EC50 values, the numbers in parentheses represent the 95% confidence intervals (CI). Rmax values are expressed as mean ± SEM of 3 to 4 assays, with 2 rats per assay.

Compound EC50 (CI) μM Rmax % of 10 μM nicotine
TC-2696 6.3 (1.2 – 31) 204 ± 43
TI-10165 0.81 (0.14 – 4.0) 78 ± 9.1
TC-8831 0.14 (0.10 – 0.26) 91 ± 3.8
TC-10600 1.49 (0.65 – 3.39) 72 ± 5.7
Sazetidinea 0.001 96 ± 6
Nicotine 3.0 (1.3 – 7.3) 100 ± 8.9
Varenicline 0.05 (0.01 – 0.20) 41 ± 5.0
a

Taken from (Zwart et al., 2008)