Table 3.
Visual function and optic nerve fibers thickness in the absence of prior history and after an optic neuritis episode
| Number of optic neuritis episodes | 0 | 1 | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| NMO (n = 10 eyes) | MS (n = 30 eyes) | P-value | NMO (n = 33 eyes) | MS (n = 19 eyes) | P-value | |
| Visual acuity (Snellen) | 20/20 | 20/20 | 0.4 | 20/50 | 20/30 | 0.02 |
| Visual acuity ETDRS | 61.1 ± 4.6 | 55.6 ± 5.6 | 0.006 | 31.4 ± 24.6 | 44.1 ± 18.6 | 0.04 |
| Visual acuity ≤20/200 | 0 | 0 | – | 14 (42.4%) | 4 (21%) | 0.03 |
| Pelli–Robson chart | 1.7 ± 0.4 | 1.6 ± 0.1 | 0.08 | 0.93 ± 0.7 | 1.2 ± 0.5 | 0.09 |
| Sloan chart 1.25% | 20.9 ± 7.1 | 12.1 ± 9.5 | 0.02 | 3 ± 5.9 | 6 ± 7.9 | 0.3 |
| Sloan chart 2.5% | 30.4 ± 11.2 | 26.2 ± 9.9 | 0.06 | 9.3 ± 13.3 | 15 ± 14 | 0.1 |
| MD (SAP) | −1.8 ± 0.9 | −3.7 ± 3.1 | 0.01 | −10.3 ± 10 | −7.9 ± 5.7 | 0.9 |
| PSD (SAP) | 2 ± 0.4 | 2.9 ± 1.4 | 0.007 | 5 ± 3.1 | 4.8 ± 2.5 | 0.9 |
| Foveal threshold | 34.4 ± 1.8 | 32.5 ± 3.1 | 0.07 | 16.2 ± 15.2 | 27.4 ± 10.4 | 0.01 |
| MD (FDTP) | −0.5 ± 3.3 | −3.1 ± 3.8 | 0.09 | −6.2 ± 5.9 | −3.4 ± 3.6 | 0.1 |
| PSD (FDTP) | 3.5 ± 0.4 | 5.6 ± 2.8 | 0.01 | 6.7 ± 3.5 | 6.2 ± 3.3 | 0.3 |
| 100-Hue | 43.7 ± 53.4 | 74.1 ± 91 | 0.4 | 91.4 ± 91.2 | 135.5 ± 142.3 | 0.3 |
| Overall average RNFL thickness (μm) | 95.6 ± 12.1 | 96.3 ± 13 | 0.5 | 64.4 ± 22.8 | 77 ± 21.2 | 0.06 |
Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; FDTP, frequency doubling technology perimetry; MD, mean deviation; MS, multiple sclerosis; NMO, neuromyelitis optica; PSD, pattern standard deviation; RNFL, retinal nerve fiber layer; SAP, standard automated perimetry.