Table 1.

Arabidopsis genes of the CIA pathway and their mutant phenotypes.

locus	gene name	yeast respectively human homologues	mutant allele(s)	phenotype	references
At5g18400	DRE2, CIAPIN1	DRE2, CIAPIN1/anamorsin	T-DNA insertion	embryo lethal	this study
At3g02280	TAH18 , ATR3	TAH18, NDOR1	T-DNA insertion	embryo lethal	[24]
At5g50960	NBP35	NBP35, NUBP2	T-DNA insertion	embryo lethal	[35,36]
At4g16440	NAR1	NAR1, IOP1/NARF	T-DNA insertion	ovule abortion or early embryo lethal	[37,38]
At2g26060	CIA1	CIA1, CIAO1	T-DNA insertion	embryo lethal	[37]
At1g68310	AE7	CIA2, MIP18	T-DNA insertion	embryo lethal	[37]
			E51K	small, chlorotic, altered leaf architecture; increased DNA damage; aconitase activity decreased, but not aldehyde oxidase	[37,39]
At3g50845 At3g09380	AE7-like1(AEL1) AE7-like2(AEL2)	—	none available	N/A	[37]
At5g48120	MET18	MET18, MMS19	T-DNA insertion	no phenotype	[37]