Table 1.
Rating Scales | Responders | Non-responders | ||
---|---|---|---|---|
Baseline Mean (SD) | End- Phase A Mean (SD) | Baseline Mean (SD) | End- Phase A Mean | |
Sum of three target symptoms | 14.5 (1.2) | 5.9 (0.9) | 14.6 (1.3) | 10.8 (3.3) |
BPRS total | 26.6 (5.5) | 19.0 (2.7) | 28.8 (6.3) | 27.2 (6.9) |
BPRS psychosis factor | 5.9 (2.5) | 3.6 (0.9) | 7.0 (3.0) | 6.2 (3.7) |
BPRS hostile suspiciousness factor | 11.1 (3.0) | 6.0 (1.2) | 11.3 (2.6) | 8.4 (2.9) |
UPDRS total | 0.8 (0.8) | 0.7 (1.0) | 0.5 (0.6) | 0.7 (0.8) |
Mini Mental State Exam (0–30) | 12.9 (6.3) | 12.3 (6.3) | 12.5 (6.0) | 13.8 (5.3) |
Target symptoms were each score on a 0–6 scale (absent to extreme), sum score range 0–18.
BPRS: Brief Psychiatric Rating Scale.
BPRS psychosis factor excluded the item for conceptual disorganization because this symptom often occurs in AD in the absence of psychosis.
UPDRS: Unified Parkinson’s Disease Rating Scale.