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. Author manuscript; available in PMC: 2013 Jun 18.
Published in final edited form as: Am J Transplant. 2011 Apr;11(4):654–659. doi: 10.1111/j.1600-6143.2011.03473.x

Figure 2. Reduced signaling through the mTOR complex alters differentiation of CD4+ T cell responses.

Figure 2

The lack of signaling through mTOR in antigen-specific CD4+ T cells leads to reduced polarization into either Th1, Th2, or Th17 T cells. In contrast, mTOR inhibition by rapamycin leads to enhanced development of regulatory T cells.