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. 2013 Jun 10;14:60. doi: 10.1186/1471-2350-14-60

Table 3.

Genetic interaction of polymorphisms and CFTR mutations in association with cystic fibrosis clinical variables

Clinical variables Gene Ratio Testing ball. acc. p-value Cross validation consistency
Male/female
CFTR*GCLC*GSTP1*GSTT1*GSTM1
1
0.5056
0.8506
10/10
Race (caucasian/ no caucasian)
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.0909
0.3909
0.9915
10/10
Age
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9889
0.5312
0.6870
10/10
Age for diagnosis
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.8804
0.4100
0.9989
10/10
Onset of symptoms
geral
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.7526
0.4286
0.9945
10/10
digestive
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9737
0.4614
0.9698
10/10
pulmonary
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.7935
0.5022
0.8566
10/10
Clinical scores
Bhalla
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9552
0.6824
0.0080#
10/10
Kanga
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9571
0.5131
0.8165
10/10
Shwachman-Kulczycki
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9
0.5562
0.5474
10/10
Body mass index
CFTR*GCLC*GSTP1*GSTT1*GSTM1
3.45
0.5484
0.6260
10/10
Sputum’s microbiology
A. xylosoxidans
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.1118
0.4617
0.9418
10/10
P. aeruginosa mucoid
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.7379
0.5505
0.5507
10/10
P. aeruginosa no mucoid
CFTR*GCLC*GSTP1*GSTT1*GSTM1
1.2949
0.4151
0.9951
10/10
S. aureus
CFTR*GCLC*GSTP1*GSTT1*GSTM1
3.7105
0.5094
0.8317
6/10
B. cepacia
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.1548
0.5277
0.7610
10/10
First isolated P. aeruginosa
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9552
0.4913
0.8903
7/10
Hemoglobin oxygen saturation in the blood
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9602
0.5312
0.6904
10/10
Spirometry
FEV1
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9848
0.4746
0.9448
10/10
FVC(%)
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.900
0.4437
0.9833
10/10
FEV1/FVC(%)
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9403
0.6426
0.0586
10/10
FEF25-75%
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.9848
0.5054
0.8447
10/10
Comorbidities
Pancreatic insufficiency
CFTR*GCLC*GSTP1*GSTT1*GSTM1
3.977
0.5266
0.7486
10/10
Meconium ileus
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.1776
0.5401
0.6950
10/10
Nasal polyps
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.2292
0.5713
0.5139
10/10
Diabetes mellitus
CFTR*GCLC*GSTP1*GSTT1*GSTM1
0.2292
0.4527
0.9728
10/10
  Osteoporosis CFTR*GCLC*GSTP1*GSTT1*GSTM1 0.1959 0.3815 0.9988 10/10

GCLC glutamate-cysteine ligase catalytic subunit, GST glutathione S-transferase, Testing Ball. Acc. Testing Balance Accuracy, CFTRCystic Fibrosis Transmembrane Regulator, A. xylosoxidansAchromobacter xylosoxidans, B. cepaciaBurkolderia cepacia, P. aeruginosaPseudomonas aeruginosa, S. aureusStaplylococcus aures, FEV1 forced expiratory volume in one second, FVC - forced vital capacity, FEF25-75% forced expiratory flow between 25 and 75% of CVF. 1. Severe variants to polymorphism: allele T, GCLC 129C>T polymorphism, allele G - GCLC-350A>G and GSTP1+313A>G polymorphisms, deletion allele GSTM1 and GSTT1 genes. # Association of GCLC-129C>T, GCLC-350A>G, GSTP1+313A>G, GSTM1 and GSTT1 genes deletion and mutations in the CFTR gene with the Bhalla Score, p: 0.0080. Statistical analysis performed by the MDR2.0 and MDRPT0.4.7 software.